OncoDefender-CRC
OncoDefender-CRC is the world's first molecular diagnostic capable of accurately distinguishing between high-risk and low-risk Stage I/II colorectal cancer tumors, thereby predicting the risk of recurrence of cancer in these patients.
OncoDefender-CRC reviewed in CANCER
Generation and External Validation of a Tumor-Derived 5-Gene Prognostic Signature for Recurrence of Lymph Node-Negative, Invasive Colorectal Carcinoma (PDF)
CONCLUSIONS: To the authors' knowledge, the 5-gene rule (OncoDefender-CRC) is the first molecular prognostic that has been validated in both stage I CRC and stage II colon cancer. It outperforms standard clinicopathologic prognostic criteria and obviates the need to retrieve 12 lymph nodes for accurate prognostication. It identifies those patients most likely to develop recurrent disease within 3 years after curative surgery and, thus, those most likely to benefit from adjuvant treatment.
Patients identified by OncoDefender-CRC as having high recurrence risk are likely to benefit from more aggressive treatment options from the start. Independent studies have demonstrated a significant improvement in overall survival rates for high-risk Stage I and Stage II colorectal cancer patients receiving adjuvant therapy within 60 days following surgical resection of their tumor. No other currently available molecular diagnostic test approaches the performance capabilities of OncoDefender-CRC in this regard.
 Patients identified by OncoDefender-CRC at high-risk of cancer recurrence may benefit from adjuvant therapy or other more aggressive treatment options. |
 The OncoDefender-CRC test will help physicians make appropriate post-surgical decisions about the need for adjuvant therapy. |
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