Author Archives: Everist Genomics
Microsatellite Instability in Determining Adjuvant Chemotherapy Sensitivity and Drug Selection MSI (Third in a series)
Microsatellites are repeated sequences that are distributed throughout the genome. When microsatellites are copied incorrectly, the Mismatch Repair (MMR) system ensures surveillance and correction of these errors and ensures microsatellite stability. Defects in the MMR system lead to microsatellite instability … Continue reading
What Is Lynch Syndrome? (Second in a series)
When normal repeated sequences of DNA are mutated and become abnormally long or shorter, genetic scientists refer to the condition as “microsatellite instability” or MSI. In technical terms, this instability results from defects in the normal DNA repair process and … Continue reading
What Is Microsatellite Instability? (First in a series)
In genetics, short tandem repeating (2-6 base pairs) sequences of DNA known as “microsatellites” are considered both normal and common. Used as molecular markers for genetic studies like kinship and population, they are typically co-dominant and have played a role … Continue reading
Is Adjuvant Chemotherapy Beneficial To Early Stage Colorectal Patients?
An original article called “Is Adjuvant Chemotherapy Beneficial To High Risk Stage II Colon Cancer” ( Lin C-C, et al. Int J Colorectal Dis; 2009, 24:665-676. reported results from an analysis in a single institute. It also investigated the benefit … Continue reading
The Role of Timing and Delays in Adjunctive Chemotherapy in Colorectal Cancer Treatment
Colorectal cancer (CRC) is the third leading cause of cancer mortality in the Western world (Global Cancer Statistics, 2002, Parkin DM, Bray F, Ferlay J, Pisani P. CA Cancer J Clin. 2005;55(2):74–108). Initially, patients with stage I-III CRC have their … Continue reading
